Title : Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes.

Pub. Date : 2014

PMID : 25520741






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In addition, Hcy stimulated the nuclear localization of Bach1 but prevented that of Nrf2. Homocysteine BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus
2 CONCLUSIONS: Collectively, our results demonstrated that Bach1 plays an important role in Hcy-triggered ROS generations through inhibiting HO-1 expression, likely, resulting from the disturbed interplay between Bach1 and Nrf2. ros BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus
3 CONCLUSIONS: Collectively, our results demonstrated that Bach1 plays an important role in Hcy-triggered ROS generations through inhibiting HO-1 expression, likely, resulting from the disturbed interplay between Bach1 and Nrf2. ros BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus