Pub. Date : 2021 Feb 17
PMID : 33596919
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Notably, the transcription factor BTB and CNC homology 1 (Bach1), a key factor in responding to conditions of oxidative stress, is increased in lung cancer after CIH exposure in vitro and in vivo. | cih | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | Mus musculus |
| 2 | Notably, the transcription factor BTB and CNC homology 1 (Bach1), a key factor in responding to conditions of oxidative stress, is increased in lung cancer after CIH exposure in vitro and in vivo. | cih | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | Mus musculus |
| 3 | Furthermore, the increase of mitochondrial ROS (mtROS) and CSC-marker expression induced by CIH exposure was abolished in Bach1 shRNA-treated lung cancer cells. | ros | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | Mus musculus |
| 4 | Furthermore, the increase of mitochondrial ROS (mtROS) and CSC-marker expression induced by CIH exposure was abolished in Bach1 shRNA-treated lung cancer cells. | cih | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | Mus musculus |
| 5 | CONCLUSIONS: Our results indicated that CIH promoted lung CSC-like properties by activating mtROS, which was partially mediated by Bach1. | cih | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | Mus musculus |