Title : BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer-promoter activity and maintains pluripotency.

Pub. Date : 2021 Feb 26

PMID : 33503260






1 Functional Relationships(s)
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Protein Name
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1 Loss of BACH1 reduced the interaction between NANOG and MLL1/SET1 complexes, and decreased their occupancy on chromatin, and further decreased H3 lysine 4 trimethylation (H3K4me3) level on gene promoters and (super-) enhancers, leading to decreased enhancer activity and transcription activity, especially on stemness-related genes. Lysine BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus