Title : Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury.

Pub. Date : 2005 Mar

PMID : 15743416






2 Functional Relationships(s)
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Protein Name
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1 In SMC, bach1-ablation resulted in increased expression of HO-1 and decreased proliferation in bromodeoxyuridine incorporation assay as compared with wild-type cells. Bromodeoxyuridine BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus
2 The up-regulated phagocytic activity and reduced SMC proliferation of bach1-deficient cells were not restored by Zinc (II) protoporphyrin IX, an inhibitor of HO, suggesting that HO-independent mechanisms are also involved in the regulation of phagocytosis of macrophages and proliferation of SMC by Bach1. zinc;3-[7,12-bis(ethenyl)-18-(3-hydroperoxyprop-1-en-2-yl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus