Title : RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice.

Pub. Date : 2017 Feb

PMID : 27836987






2 Functional Relationships(s)
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1 Therefore, we hypothesized that RANKL could be involved in the nuclear translocation of Bach1, which would attenuate Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular ROS signaling in osteoclasts. Reactive Oxygen Species BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus
2 Induction of Bach1 nuclear export increased Nrf2 nuclear import, augmented antioxidant enzyme expression, and, thus, diminished RANKL-mediated osteoclastogenesis via attenuated intracellular ROS signaling. Reactive Oxygen Species BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus