polypeptide N-acetylgalactosaminyltransferase 2 ; Homo sapiens






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1 12438318 Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. J Biol Chem 2003 Feb 21 1
2 12507512 Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14. Biochem Biophys Res Commun 2003 Jan 17 1
3 15044392 Basic amino acids as modulators of an O-linked glycosylation signal of the herpes simplex virus type 1 glycoprotein gC: functional roles in viral infectivity. Glycobiology 2004 Jul 1
4 17215257 The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation. Glycobiology 2007 Apr 4
5 18322546 B-cell O-galactosyltransferase activity, and expression of O-glycosylation genes in bone marrow in IgA nephropathy. Kidney Int 2008 May 2
6 19487539 Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet 2009 Jun 1
7 19656773 A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia. Hum Mol Genet 2009 Nov 1 1
8 20735851 Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins--towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation. BMC Biotechnol 2010 Aug 24 7
9 21532840 A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies. Int J Mol Epidemiol Genet 2010 Jul 26 2
10 21699783 TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease. Gastroenterology 2011 Sep 1
11 21874244 regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2. Mol Med Rep 2011 Nov-Dec 1
12 21933382 Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations. Lipids Health Dis 2011 Sep 20 1
13 21990321 Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor. Cancer Res 2011 Dec 1 3
14 22033505 Production of N-acetylgalactosaminyl-transferase 2 (GalNAc-T2) fused with secretory signal Igκ in insect cells. Protein Expr Purif 2012 Feb 3
15 22152306 Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. Cell Metab 2011 Dec 7 3
16 22952570 Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol. PLoS One 2012 1
17 23117232 Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion. Placenta 2012 Dec 6
18 23382687 Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. PLoS Genet 2013 2
19 23894607 GALNT2 expression is reduced in patients with Type 2 diabetes: possible role of hyperglycemia. PLoS One 2013 5
20 24643241 A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2. Org Biomol Chem 2014 May 7 4
21 24906187 Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. Environ Health Perspect 2014 Oct 1
22 25362349 GALNT2 suppresses malignant phenotypes through IGF-1 receptor and predicts favorable prognosis in neuroblastoma. Oncotarget 2014 Dec 15 1
23 25548287 O-linked glycosylation of the mucin domain of the herpes simplex virus type 1-specific glycoprotein gC-1 is temporally regulated in a seed-and-spread manner. J Biol Chem 2015 Feb 20 2
24 25744272 Role of let-7b in the regulation of N-acetylgalactosaminyltransferase 2 in IgA nephropathy. Nephrol Dial Transplant 2015 Jul 8
25 25939779 Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation. Nat Commun 2015 May 5 2
26 26239958 GALNT2 mRNA levels are associated with serum triglycerides in humans. Endocrine 2016 Jul 1
27 27071848 Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates. Chemistry 2016 May 17 3
28 28153384 GALNT2 effect on HDL-cholesterol and triglycerides levels in humans: Evidence of pleiotropy? Nutr Metab Cardiovasc Dis 2017 Apr 5
29 28167537 Site-specific <i>O</i>-Glycosylation by Polypeptide <i>N</i>-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β<sub>1</sub>-Adrenergic Receptor N-terminal Cleavage. J Biol Chem 2017 Mar 17 3
30 28333714 Novel regulators of plasma lipid levels. Curr Opin Lipidol 2017 Jun 2
31 28915626 HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in <i>CETP, ABCA1, APOC3,</i> and <i>GALNT2</i>. Oncotarget 2017 Aug 22 1
32 29039611 Altered expression of different GalNAc‑transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer. Int J Oncol 2017 Dec 1
33 29208955 The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. Nat Commun 2017 Dec 5 1
34 29601100 Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts. Chemistry 2018 Jun 12 2
35 30275900 Epigenome wide association study of SNP-CpG interactions on changes in triglyceride levels after pharmaceutical intervention: a GAW20 analysis. BMC Proc 2018 1
36 30327431 Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the <i>O</i>-glycoproteome by inducible expression in isogenic cell lines. J Biol Chem 2018 Dec 7 1
37 30759204 IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2. Glycobiology 2019 Jul 1 4
38 31279243 Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder. J Psychiatr Res 2019 Oct 1
39 32293671 Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function. Brain 2020 Apr 1 2
40 32329196 O-glycan initiation directs distinct biological pathways and controls epithelial differentiation. EMBO Rep 2020 Jun 4 1
41 33171515 GALNT2 Gene Variant rs4846914 Is Associated with Insulin and Insulin Resistance Depending on BMI in PCOS Patients: a Case-Control Study. Reprod Sci 2021 Apr 1
42 33964375 GALNT2/14 overexpression correlate with prognosis and methylation: potential therapeutic targets for lung adenocarcinoma. Gene 2021 Jul 20 1
43 34585120 Genetic risk model for in-stent restenosis of second-and third-generation drug-eluting stents. iScience 2021 Sep 24 1
44 34850523 Novel Quinic Acid Glycerates from Tussilago farfara Inhibit Polypeptide GalNAc-Transferase. Chembiochem 2022 Feb 4 2
45 35370688 A Pharmacoinformatics Analysis of Artemisinin Targets and <i>de novo</i> Design of Hits for Treating Ulcerative Colitis. Front Pharmacol 2022 4
46 35373202 Atomic and Specificity Details of Mucin 1 <i>O</i>-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling. JACS Au 2022 Mar 28 1