Title : Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion.

Pub. Date : 2012 Dec

PMID : 23117232






6 Functional Relationships(s)
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1 Here, we found that the GALNT1 and GALNT2 mRNA were highly expressed in HTR8/SVneo and first trimester EVT cells. EVT polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
2 Immunohistochemstry and immunofluorescence staining showed that GALNT2 was expressed in subpopulations of EVT cells in deciduas, but not in syncytiotrophoblasts and cytotrophoblasts of placental villi. EVT polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
3 Notably, we found that GALNT2 increased the expression of Tn antigen (GalNAc-Ser/Thr) on beta1-integrin as revealed by Vicia Villosa agglutinin (VVA) binding. N-acetylgalactosaminuronic acid polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
4 Notably, we found that GALNT2 increased the expression of Tn antigen (GalNAc-Ser/Thr) on beta1-integrin as revealed by Vicia Villosa agglutinin (VVA) binding. Serine polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
5 Notably, we found that GALNT2 increased the expression of Tn antigen (GalNAc-Ser/Thr) on beta1-integrin as revealed by Vicia Villosa agglutinin (VVA) binding. Threonine polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
6 Our findings suggest that GALNT2 is a critical initiating enzyme of O-glycosylation for regulating EVT invasion. EVT polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens