Title : IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2.

Pub. Date : 2019 Jul 1

PMID : 30759204






4 Functional Relationships(s)
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1 IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2. Polysaccharides polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
2 The lectin domain predominately enhanced IgA1 HR glycan density by increasing synthesis pathway exploration by GalNAc-T2. Polysaccharides polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
3 Our data indicated a link between site-specific glycan addition and clustered glycan density that defines a mechanism of how conserved clustered O-glycosylation patterns and glycoform populations of IgA1 can be controlled by GalNAc-T2. Polysaccharides polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens
4 Our data indicated a link between site-specific glycan addition and clustered glycan density that defines a mechanism of how conserved clustered O-glycosylation patterns and glycoform populations of IgA1 can be controlled by GalNAc-T2. Polysaccharides polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens