beta-thujaplicin






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1 342032 The uptake kinetics and metabolism of extraneuronal noradrenaline in guinea-pig trachea as studied with quantitative fluorescence microphotometry. Br J Pharmacol 1978 Feb 1
2 9424082 Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. J Invest Dermatol 1998 Jan 2
3 10371304 Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Cell Prolif 1999 Feb 3
4 15089040 (-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production. Arch Pharm Res 2004 Mar 5
5 16171776 Arachidonate 12-lipoxygenases with reference to their selective inhibitors. Biochem Biophys Res Commun 2005 Dec 9 1
6 16327152 Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis. Biol Pharm Bull 2005 Dec 1
7 16781122 Differential regulation of melanosomal proteins after hinokitiol treatment. J Dermatol Sci 2006 Sep 13
8 17055455 Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines. Biochem Biophys Res Commun 2006 Dec 8 1
9 18537078 Hinokitiol, a natural tropolone derivative, inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB. Planta Med 2008 Jun 3
10 19631451 p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function. Cancer Lett 2009 Dec 28 3
11 20416277 Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases. Biochem Biophys Res Commun 2010 May 28 6
12 21069157 Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes. Metallomics 2010 Mar 1
13 22419431 Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts. Am J Chin Med 2012 4
14 22507316 In vitro and in vivo therapeutics of β-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice. Int J Immunopathol Pharmacol 2012 Jan-Mar 8
15 23473801 Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo. Biochem Pharmacol 2013 May 15 4
16 24370180 Hinokitiol increases the angiogenic potential of dental pulp cells through ERK and p38MAPK activation and hypoxia-inducible factor-1α (HIF-1α) upregulation. Arch Oral Biol 2014 Feb 8
17 24433214 Hinokitiol is a novel glycoprotein VI antagonist on human platelets. Platelets 2014 5
18 25105411 Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS One 2014 1
19 25169829 Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo. Int Immunopharmacol 2014 Nov 5
20 25449038 Hinokitiol, a tropolone derivative, inhibits mouse melanoma (B16-F10) cell migration and in vivo tumor formation. Eur J Pharmacol 2015 Jan 5 8
21 25666914 β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells. Biosci Biotechnol Biochem 2015 5
22 25961161 Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells. Molecules 2015 May 7 4
23 26379747 Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes. Evid Based Complement Alternat Med 2015 2
24 26404213 Hinokitiol Exerts Anticancer Activity through Downregulation of MMPs 9/2 and Enhancement of Catalase and SOD Enzymes: In Vivo Augmentation of Lung Histoarchitecture. Molecules 2015 Sep 25 4
25 26901194 Hinokitiol Inhibits Melanogenesis via AKT/mTOR Signaling in B16F10 Mouse Melanoma Cells. Int J Mol Sci 2016 Feb 18 7
26 27073579 Hinokitiol inhibits vasculogenic mimicry activity of breast cancer stem/progenitor cells through proteasome-mediated degradation of epidermal growth factor receptor. Oncol Lett 2016 Apr 1
27 27269503 Protective Role of Hinokitiol Against H<sub>2</sub>O<sub>2</sub>-Induced Injury in Human Corneal Epithelium. Curr Eye Res 2017 Jan 1
28 28241740 Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC Cell Biol 2017 Feb 27 2
29 28257794 SIRT1, a Class III Histone Deacetylase, Regulates LPS-Induced Inflammation in Human Keratinocytes and Mediates the Anti-Inflammatory Effects of Hinokitiol. J Invest Dermatol 2017 Jun 7
30 28381806 Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles. Biol Pharm Bull 2017 1
31 28685346 Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation. Cancer Chemother Pharmacol 2017 Aug 3
32 28773431 Hinokitiol-Loaded Mesoporous Calcium Silicate Nanoparticles Induce Apoptotic Cell Death through Regulation of the Function of MDR1 in Lung Adenocarcinoma Cells. Materials (Basel) 2016 Apr 25 1
33 29100291 Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells. Oncotarget 2017 Sep 29 3
34 29112893 Natural product β-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy. DNA Repair (Amst) 2017 Dec 3
35 29288721 Treatment of β-thujaplicin counteracts di(2-ethylhexyl)phthalate (DEHP)-exposed vascular smooth muscle activation, inflammation and atherosclerosis progression. Regul Toxicol Pharmacol 2018 Feb 3
36 29565268 Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis. Int J Mol Sci 2018 Mar 22 10
37 29765446 Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53. Arch Med Sci 2018 Apr 4
38 30548082 New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury. J Cell Mol Med 2019 Mar 16
39 30569287 Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes. Neurotox Res 2019 May 12
40 30684529 Hinokitiol suppresses growth of B16 melanoma by activating ERK/MKP3/proteosome pathway to downregulate survivin expression. Toxicol Appl Pharmacol 2019 Mar 1 12
41 30714720 Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens. Biochemistry 2019 Mar 5 1
42 30761254 Transferrin receptor 1 is required for enucleation of mouse erythroblasts during terminal differentiation. FEBS Open Bio 2019 Feb 1
43 30874538 β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma. Cell Death Dis 2019 Mar 15 10
44 31026007 β-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3β/β-catenin signaling. Food Funct 2019 May 22 14
45 32917321 Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma. Taiwan J Obstet Gynecol 2020 Sep 13
46 33012507 Drosophila ZnT1 is essential in the intestine for dietary zinc absorption. Biochem Biophys Res Commun 2020 Dec 17 1
47 33628376 Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration <i>In Vivo</i>. Oxid Med Cell Longev 2021 2
48 33809876 Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products. Biomolecules 2021 Mar 22 1
49 33831806 Hinokitiol inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo. Int Immunopharmacol 2021 Jul 7
50 34055782 JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration. Front Cell Dev Biol 2021 1