Pub. Date : 2019 May 22
PMID : 31026007
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3beta/beta-catenin signaling. | beta-thujaplicin | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | beta-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3beta/beta-catenin signaling. | beta-thujaplicin | catenin beta 1 | Homo sapiens |
| 3 | Here, we investigated the effect of beta-thujaplicin on inhibiting ER-negative basal-like breast cancer and the underlying mechanism of action using an in vitro and in vivo xenograft animal model. | beta-thujaplicin | estrogen receptor 1 | Homo sapiens |
| 4 | beta-Thujaplicin induced G0/G1 phase cell cycle arrest and regulated cell cycle mediators, cyclin D1, cyclin E, and cyclin-dependent kinase 4 (CDK 4), leading to the inhibition of the proliferation of ER-negative basal-like MCF10DCIS.com human breast cancer cells. | beta-thujaplicin | cyclin D1 | Homo sapiens |
| 5 | beta-Thujaplicin induced G0/G1 phase cell cycle arrest and regulated cell cycle mediators, cyclin D1, cyclin E, and cyclin-dependent kinase 4 (CDK 4), leading to the inhibition of the proliferation of ER-negative basal-like MCF10DCIS.com human breast cancer cells. | beta-thujaplicin | cyclin dependent kinase 4 | Homo sapiens |
| 6 | beta-Thujaplicin induced G0/G1 phase cell cycle arrest and regulated cell cycle mediators, cyclin D1, cyclin E, and cyclin-dependent kinase 4 (CDK 4), leading to the inhibition of the proliferation of ER-negative basal-like MCF10DCIS.com human breast cancer cells. | beta-thujaplicin | cyclin dependent kinase 4 | Homo sapiens |
| 7 | beta-Thujaplicin induced G0/G1 phase cell cycle arrest and regulated cell cycle mediators, cyclin D1, cyclin E, and cyclin-dependent kinase 4 (CDK 4), leading to the inhibition of the proliferation of ER-negative basal-like MCF10DCIS.com human breast cancer cells. | beta-thujaplicin | estrogen receptor 1 | Homo sapiens |
| 8 | In an MCF10DCIS.com xenograft animal model, beta-thujaplicin significantly inhibited tumor growth, reduced tumor weight, and regulated the expression of cell cycle proteins, phosphorylation of AKT and GSK-3beta, and protein level of beta-catenin in the tumor tissues. | beta-thujaplicin | AKT serine/threonine kinase 1 | Homo sapiens |
| 9 | In an MCF10DCIS.com xenograft animal model, beta-thujaplicin significantly inhibited tumor growth, reduced tumor weight, and regulated the expression of cell cycle proteins, phosphorylation of AKT and GSK-3beta, and protein level of beta-catenin in the tumor tissues. | beta-thujaplicin | glycogen synthase kinase 3 alpha | Homo sapiens |
| 10 | In an MCF10DCIS.com xenograft animal model, beta-thujaplicin significantly inhibited tumor growth, reduced tumor weight, and regulated the expression of cell cycle proteins, phosphorylation of AKT and GSK-3beta, and protein level of beta-catenin in the tumor tissues. | beta-thujaplicin | catenin beta 1 | Homo sapiens |
| 11 | These results demonstrate that beta-thujaplicin can suppress basal-like mammary tumor growth by regulating GSK-3beta/beta-catenin signaling, suggesting that beta-thujaplicin may be a potent chemopreventive agent against the basal-like subtype of breast cancer. | beta-thujaplicin | glycogen synthase kinase 3 alpha | Homo sapiens |
| 12 | These results demonstrate that beta-thujaplicin can suppress basal-like mammary tumor growth by regulating GSK-3beta/beta-catenin signaling, suggesting that beta-thujaplicin may be a potent chemopreventive agent against the basal-like subtype of breast cancer. | beta-thujaplicin | catenin beta 1 | Homo sapiens |
| 13 | These results demonstrate that beta-thujaplicin can suppress basal-like mammary tumor growth by regulating GSK-3beta/beta-catenin signaling, suggesting that beta-thujaplicin may be a potent chemopreventive agent against the basal-like subtype of breast cancer. | beta-thujaplicin | glycogen synthase kinase 3 alpha | Homo sapiens |
| 14 | These results demonstrate that beta-thujaplicin can suppress basal-like mammary tumor growth by regulating GSK-3beta/beta-catenin signaling, suggesting that beta-thujaplicin may be a potent chemopreventive agent against the basal-like subtype of breast cancer. | beta-thujaplicin | catenin beta 1 | Homo sapiens |