Title : New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury.

Pub. Date : 2019 Mar

PMID : 30548082






16 Functional Relationships(s)
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Protein Name
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1 Hinokitiol could inhibited NF-kappaB activation and IL-6 and TNF-alpha upregulation in liver tissues. beta-thujaplicin nuclear factor kappa B subunit 1 Homo sapiens
2 Hinokitiol could inhibited NF-kappaB activation and IL-6 and TNF-alpha upregulation in liver tissues. beta-thujaplicin interleukin 6 Homo sapiens
3 Hinokitiol could inhibited NF-kappaB activation and IL-6 and TNF-alpha upregulation in liver tissues. beta-thujaplicin tumor necrosis factor Homo sapiens
4 Moreover, hinokitiol reduced caspase-3 activation, upregulated Bax and downregulated Bcl-2. beta-thujaplicin caspase 3 Homo sapiens
5 Moreover, hinokitiol reduced caspase-3 activation, upregulated Bax and downregulated Bcl-2. beta-thujaplicin BCL2 associated X, apoptosis regulator Homo sapiens
6 Moreover, hinokitiol reduced caspase-3 activation, upregulated Bax and downregulated Bcl-2. beta-thujaplicin BCL2 apoptosis regulator Homo sapiens
7 Hinokitiol prevented H/R-induced caspase-3 activation, PPAR cleavage, Bax overexpression and Bcl-2 downregulation. beta-thujaplicin caspase 3 Homo sapiens
8 Hinokitiol prevented H/R-induced caspase-3 activation, PPAR cleavage, Bax overexpression and Bcl-2 downregulation. beta-thujaplicin peroxisome proliferator activated receptor alpha Homo sapiens
9 Hinokitiol prevented H/R-induced caspase-3 activation, PPAR cleavage, Bax overexpression and Bcl-2 downregulation. beta-thujaplicin BCL2 associated X, apoptosis regulator Homo sapiens
10 Hinokitiol prevented H/R-induced caspase-3 activation, PPAR cleavage, Bax overexpression and Bcl-2 downregulation. beta-thujaplicin BCL2 apoptosis regulator Homo sapiens
11 Moreover, hinokitiol attenuated H/R-stimulated NF-kappaB activation and reduced the levels of IL-6 and TNF-alpha mRNAs, suggesting that hinokitiol can protect hepatocytes from H/R injury. beta-thujaplicin nuclear factor kappa B subunit 1 Homo sapiens
12 Moreover, hinokitiol attenuated H/R-stimulated NF-kappaB activation and reduced the levels of IL-6 and TNF-alpha mRNAs, suggesting that hinokitiol can protect hepatocytes from H/R injury. beta-thujaplicin interleukin 6 Homo sapiens
13 Moreover, hinokitiol attenuated H/R-stimulated NF-kappaB activation and reduced the levels of IL-6 and TNF-alpha mRNAs, suggesting that hinokitiol can protect hepatocytes from H/R injury. beta-thujaplicin tumor necrosis factor Homo sapiens
14 Moreover, hinokitiol attenuated H/R-stimulated NF-kappaB activation and reduced the levels of IL-6 and TNF-alpha mRNAs, suggesting that hinokitiol can protect hepatocytes from H/R injury. beta-thujaplicin interleukin 6 Homo sapiens
15 Moreover, hinokitiol attenuated H/R-stimulated NF-kappaB activation and reduced the levels of IL-6 and TNF-alpha mRNAs, suggesting that hinokitiol can protect hepatocytes from H/R injury. beta-thujaplicin tumor necrosis factor Homo sapiens
16 Collectively, our data suggest that hinokitiol attenuates liver injury following HS/R, partly through the inhibition of NF-kappaB activation. beta-thujaplicin nuclear factor kappa B subunit 1 Homo sapiens