Pub. Date : 2019 Mar 15
PMID : 30874538
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further using beta-Thujaplicin combined with an autophagy blocker or agonist treatment HepG2 cells, we found that beta-Thujaplicin induced autophagic cell death (ACD) mediated by ROS caused inhibition of the Akt-mTOR signaling pathway. | beta-thujaplicin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Moreover, beta-Thujaplicin triggered HepG2 apoptosis and increased cleaved PARP1, cleaved caspase-3, and Bax/Bcl-2 ratio, which indicated that beta-Thujaplicin induced apoptosis mediated by the mitochondrial-dependent pathway. | beta-thujaplicin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | Moreover, beta-Thujaplicin triggered HepG2 apoptosis and increased cleaved PARP1, cleaved caspase-3, and Bax/Bcl-2 ratio, which indicated that beta-Thujaplicin induced apoptosis mediated by the mitochondrial-dependent pathway. | beta-thujaplicin | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 4 | Moreover, beta-Thujaplicin triggered HepG2 apoptosis and increased cleaved PARP1, cleaved caspase-3, and Bax/Bcl-2 ratio, which indicated that beta-Thujaplicin induced apoptosis mediated by the mitochondrial-dependent pathway. | beta-thujaplicin | BCL2 apoptosis regulator | Homo sapiens |
| 5 | Moreover, beta-Thujaplicin triggered HepG2 apoptosis and increased cleaved PARP1, cleaved caspase-3, and Bax/Bcl-2 ratio, which indicated that beta-Thujaplicin induced apoptosis mediated by the mitochondrial-dependent pathway. | beta-thujaplicin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 6 | Moreover, beta-Thujaplicin triggered HepG2 apoptosis and increased cleaved PARP1, cleaved caspase-3, and Bax/Bcl-2 ratio, which indicated that beta-Thujaplicin induced apoptosis mediated by the mitochondrial-dependent pathway. | beta-thujaplicin | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 7 | Moreover, beta-Thujaplicin triggered HepG2 apoptosis and increased cleaved PARP1, cleaved caspase-3, and Bax/Bcl-2 ratio, which indicated that beta-Thujaplicin induced apoptosis mediated by the mitochondrial-dependent pathway. | beta-thujaplicin | BCL2 apoptosis regulator | Homo sapiens |
| 8 | We also found that increased expression of p21 and decreased expression of CDK7, Cyclin D1, and Cyclin A2 participating in beta-Thujaplicin caused the S-phase arrest. | beta-thujaplicin | cyclin dependent kinase 7 | Homo sapiens |
| 9 | We also found that increased expression of p21 and decreased expression of CDK7, Cyclin D1, and Cyclin A2 participating in beta-Thujaplicin caused the S-phase arrest. | beta-thujaplicin | cyclin D1 | Homo sapiens |
| 10 | We also found that increased expression of p21 and decreased expression of CDK7, Cyclin D1, and Cyclin A2 participating in beta-Thujaplicin caused the S-phase arrest. | beta-thujaplicin | cyclin A2 | Homo sapiens |