Pub. Date : 2019 Dec 3
PMID : 31816863
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Celecoxib reduced cell growth and induced apoptosis through AKT blockade, cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), and proteasomal degradation of the anti-apoptotic protein Mcl-1. | celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | RESULTS: Celecoxib reduced cell growth and induced apoptosis through AKT blockade, cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), and proteasomal degradation of the anti-apoptotic protein Mcl-1. | celecoxib | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | RESULTS: Celecoxib reduced cell growth and induced apoptosis through AKT blockade, cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), and proteasomal degradation of the anti-apoptotic protein Mcl-1. | celecoxib | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | RESULTS: Celecoxib reduced cell growth and induced apoptosis through AKT blockade, cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), and proteasomal degradation of the anti-apoptotic protein Mcl-1. | celecoxib | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 5 | Celecoxib reduced the invasive phenotype of CRPC cells by modulating NF-kappaB activity and reduced tumor growth in mice xenografts when administered in association with the anti-EGFR receptor antibody cetuximab. | celecoxib | epidermal growth factor receptor | Mus musculus |