Pub. Date : 2019 Sep 25
PMID : 31348918
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MC congeners, currently >240 known, differ dramatically in their uptake kinetics, i.e. their uptake via OATP1B1 and OATP1B3, in OATP overexpressing human HEK293 cells and primary human hepatocytes. | microcystin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | MC congeners, currently >240 known, differ dramatically in their uptake kinetics, i.e. their uptake via OATP1B1 and OATP1B3, in OATP overexpressing human HEK293 cells and primary human hepatocytes. | microcystin | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 3 | It is thus likely that MC congeners will also differ with respect to the cellular efflux of the parent and conjugated congeners, e.g. via MRPs, MDRs, BCRP or BSEP. | microcystin | BCR pseudogene 1 | Homo sapiens |
| 4 | It is thus likely that MC congeners will also differ with respect to the cellular efflux of the parent and conjugated congeners, e.g. via MRPs, MDRs, BCRP or BSEP. | microcystin | ATP binding cassette subfamily B member 11 | Homo sapiens |
| 5 | Consequently, the role and kinetics of different human efflux transporters - MRP, MDR, BCRP and BSEP in MC efflux was studied using insect membrane vesicles overexpressing the human transporters of interest. | microcystin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 6 | Consequently, the role and kinetics of different human efflux transporters - MRP, MDR, BCRP and BSEP in MC efflux was studied using insect membrane vesicles overexpressing the human transporters of interest. | microcystin | BCR pseudogene 1 | Homo sapiens |
| 7 | Consequently, the role and kinetics of different human efflux transporters - MRP, MDR, BCRP and BSEP in MC efflux was studied using insect membrane vesicles overexpressing the human transporters of interest. | microcystin | ATP binding cassette subfamily B member 11 | Homo sapiens |
| 8 | Of the efflux transporters investigated, MRP2 displayed MC transport. | microcystin | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 9 | MC transport by MRP2 was MC congener-specific, whereby MC-LF was transported more rapidly than MC-LR and -RR. | microcystin | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 10 | MC transport by MRP2 was MC congener-specific, whereby MC-LF was transported more rapidly than MC-LR and -RR. | microcystin | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 11 | MC transport by MRP2 was MC congener-specific, whereby MC-LF was transported more rapidly than MC-LR and -RR. | microcystin | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 12 | Although MRP2 showed specific MC transport, the MC-LR-GSH conjugate, was not transported suggesting the involvement of other transporters than MRP2 for the conjugate efflux. | microcystin | ATP binding cassette subfamily C member 2 | Homo sapiens |