CPRiL

ABCB11

ATP binding cassette subfamily B member 11

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

• bile salt export pump
• ABC member 16, MDR/TAP subfamily
• ATP-binding cassette sub-family B member 11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
progressive familial intrahepatic cholestasis 2
sister p-glycoprotein
ABC16
BRIC2
BSEP
PFIC-2
PFIC2
PGY4
SPGP