| Protein Name | solute carrier organic anion transporter family member 1B3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 28234 |
| Gene Symbol | SLCO1B3 |
| UniProt | Q9NPD5 (SO1B3_HUMAN), B3KP78 (B3KP78_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
344
Total Number of Articles : 374 |
Description |
solute carrier organic anion transporter family member 1B3 |
| Gene Summary |
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017] |
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