Protein Name solute carrier organic anion transporter family member 1B3
Organism Homo sapiens
Gene ID 28234
Gene Symbol

SLCO1B3

UniProt Q9NPD5 (SO1B3_HUMAN), B3KP78 (B3KP78_HUMAN)
Relationships Total Number of functionally related compound(s) : 344
Total Number of Articles : 374
Description

solute carrier organic anion transporter family member 1B3

Gene Summary

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017]

synonyms
  • solute carrier organic anion transporter family member 1B3
  • liver-specific organic anion transporter 2
  • liver-specific organic anion transporter 3TM13
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Properties