Pub. Date : 2012 Jun 29
PMID : 22640737
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A second generation PARP inhibitor, GPI 15427, was administrated to mice to investigate the possible mechanisms underlying its neuroprotective effects after retinal I/R injury. | GPI 15427 | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | GPI 15427 inhibited the retinal I/R-induced PARP activation and glial cell activation. | GPI 15427 | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | I/R-induced PERK-eIF2alpha-CHOP activation and Bip over-expression were inhibited by GPI 15427, while it did not suppress I/R-induced CHOP over-expression and degeneration of retinal capillaries. | GPI 15427 | eukaryotic translation initiation factor 2 alpha kinase 3 | Mus musculus |
| 4 | I/R-induced PERK-eIF2alpha-CHOP activation and Bip over-expression were inhibited by GPI 15427, while it did not suppress I/R-induced CHOP over-expression and degeneration of retinal capillaries. | GPI 15427 | eukaryotic translation initiation factor 2A | Mus musculus |
| 5 | I/R-induced PERK-eIF2alpha-CHOP activation and Bip over-expression were inhibited by GPI 15427, while it did not suppress I/R-induced CHOP over-expression and degeneration of retinal capillaries. | GPI 15427 | DNA-damage inducible transcript 3 | Mus musculus |
| 6 | I/R-induced PERK-eIF2alpha-CHOP activation and Bip over-expression were inhibited by GPI 15427, while it did not suppress I/R-induced CHOP over-expression and degeneration of retinal capillaries. | GPI 15427 | heat shock protein 5 | Mus musculus |
| 7 | Our results suggest that GPI 15427 inhibited retinal I/R-induced neurodegeneration and glial cell activation, and this was associated with an effect of the drug to suppress PERK-eIF2alpha-CHOP activation and Bip over-expression. | GPI 15427 | eukaryotic translation initiation factor 2 alpha kinase 3 | Mus musculus |
| 8 | Our results suggest that GPI 15427 inhibited retinal I/R-induced neurodegeneration and glial cell activation, and this was associated with an effect of the drug to suppress PERK-eIF2alpha-CHOP activation and Bip over-expression. | GPI 15427 | eukaryotic translation initiation factor 2A | Mus musculus |
| 9 | Our results suggest that GPI 15427 inhibited retinal I/R-induced neurodegeneration and glial cell activation, and this was associated with an effect of the drug to suppress PERK-eIF2alpha-CHOP activation and Bip over-expression. | GPI 15427 | DNA-damage inducible transcript 3 | Mus musculus |
| 10 | Our results suggest that GPI 15427 inhibited retinal I/R-induced neurodegeneration and glial cell activation, and this was associated with an effect of the drug to suppress PERK-eIF2alpha-CHOP activation and Bip over-expression. | GPI 15427 | heat shock protein 5 | Mus musculus |