| Protein Name | DNA-damage inducible transcript 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13198 |
| Gene Symbol | Ddit3 |
| UniProt | P35639 (DDIT3_MOUSE), Q3V405 (Q3V405_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
383
Total Number of Articles : 534 |
Description |
DNA-damage inducible transcript 3 |
| Gene Summary |
Enables several functions, including DNA-binding transcription factor binding activity; protein heterodimerization activity; and transcription regulator activator activity. Involved in several processes, including blood vessel development; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including ER overload response; diaphragm contraction; and negative regulation of fat cell differentiation. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Jul 2025] |
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