Protein Name heat shock protein 5
Organism Mus musculus
Gene ID 14828
Gene Symbol

Hspa5

UniProt P20029 (BIP_MOUSE), Q3U7T8 (Q3U7T8_MOUSE)
Relationships Total Number of functionally related compound(s) : 360
Total Number of Articles : 505
Description

heat shock protein 5

Gene Summary

Enables misfolded protein binding activity and ribosome binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; cerebellum development; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including cellular response to interleukin-4; negative regulation of transforming growth factor beta receptor signaling pathway; and toxin transport. Located in several cellular components, including cell surface; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • endoplasmic reticulum chaperone BiP
  • 78 kDa glucose-regulated protein
  • GRP-78
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Properties