Protein Name eukaryotic translation initiation factor 2 alpha kinase 3
Organism Mus musculus
Gene ID 13666
Gene Symbol

Eif2ak3

UniProt Q9Z2B5 (E2AK3_MOUSE), Q7TQC8 (Q7TQC8_MOUSE), E9QQ30 (E9QQ30_MOUSE), A0A0R4J1Y1 (A0A0R4J1Y1_MOUSE)
Relationships Total Number of functionally related compound(s) : 348
Total Number of Articles : 436
Description

eukaryotic translation initiation factor 2 alpha kinase 3

Gene Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

synonyms
  • eukaryotic translation initiation factor 2-alpha kinase 3
  • PRKR-like endoplasmic reticulum kinase
  • pancreatic eIF2-alpha kinase
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Properties