Pub. Date : 2008 Nov
PMID : 19138991
17 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. | flavokawain A | tumor protein p53 | Homo sapiens |
| 2 | In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. | flavokawain A | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. | flavokawain A | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. | flavokawain A | interferon alpha inducible protein 27 | Homo sapiens |
| 5 | In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. | flavokawain A | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 6 | In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. | flavokawain A | cyclin dependent kinase 2 | Homo sapiens |
| 7 | In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest. | flavokawain A | cyclin dependent kinase 2 | Homo sapiens |
| 8 | In contrast, flavokawain A induced a G(2)-M arrest in six p53 mutant-type, high-grade bladder cancer cell lines (T24, UMUC3, TCCSUP, 5637, HT1376, and HT1197). | flavokawain A | tumor protein p53 | Homo sapiens |
| 9 | Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |
| 10 | Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. | flavokawain A | myelin transcription factor 1 | Homo sapiens |
| 11 | Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. | flavokawain A | WEE1 G2 checkpoint kinase | Homo sapiens |
| 12 | Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. | flavokawain A | cyclin B1 | Homo sapiens |
| 13 | Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |
| 14 | Suppression of p53 expression by small interfering RNA in RT4 cells restored Cdc25C expression and down-regulated p21/WAF1 expression, which allowed Cdc25C and CDK1 activation, which then led to a G(2)-M arrest and an enhanced growth-inhibitory effect by flavokawain A. | flavokawain A | tumor protein p53 | Homo sapiens |
| 15 | Consistently, flavokawain A also caused a pronounced CDK1 activation and G(2)-M arrest in p53 knockout but not in p53 wild-type HCT116 cells. | flavokawain A | cyclin dependent kinase 1 | Homo sapiens |
| 16 | Consistently, flavokawain A also caused a pronounced CDK1 activation and G(2)-M arrest in p53 knockout but not in p53 wild-type HCT116 cells. | flavokawain A | tumor protein p53 | Homo sapiens |
| 17 | This selectivity of flavokawain A for inducing a G(2)-M arrest in p53-defective cells deserves further investigation as a new mechanism for the prevention and treatment of bladder cancer. | flavokawain A | tumor protein p53 | Homo sapiens |