Protein Name cyclin dependent kinase inhibitor 1B
Organism Homo sapiens
Gene ID 1027
Gene Symbol

CDKN1B

UniProt P46527 (CDN1B_HUMAN), Q6I9V6 (Q6I9V6_HUMAN)
Relationships Total Number of functionally related compound(s) : 588
Total Number of Articles : 1005
Description

cyclin dependent kinase inhibitor 1B

Gene Summary

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

synonyms
  • cyclin-dependent kinase inhibitor 1B
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • CDKN4
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Properties