PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19138991-3	2008	In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest.	flavokawain A	77-90	tumor protein p53	Homo sapiens	5-8	
19138991-3	2008	In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest.	flavokawain A	77-90	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-104	
19138991-3	2008	In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest.	flavokawain A	77-90	cyclin dependent kinase inhibitor 1A	Homo sapiens	105-109	
19138991-3	2008	In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest.	flavokawain A	77-90	interferon alpha inducible protein 27	Homo sapiens	114-117	
19138991-3	2008	In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest.	flavokawain A	77-90	cyclin dependent kinase inhibitor 1B	Homo sapiens	118-122	
19138991-3	2008	In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest.	flavokawain A	77-90	cyclin dependent kinase 2	Homo sapiens	156-181	
19138991-3	2008	In a p53 wild-type, low-grade, and papillary bladder cancer cell line (RT4), flavokawain A increased p21/WAF1 and p27/KIP1, which resulted in a decrease in cyclin-dependent kinase-2 (CDK2) kinase activity and subsequent G(1) arrest.	flavokawain A	77-90	cyclin dependent kinase 2	Homo sapiens	183-187	
19138991-6	2008	In contrast, flavokawain A induced a G(2)-M arrest in six p53 mutant-type, high-grade bladder cancer cell lines (T24, UMUC3, TCCSUP, 5637, HT1376, and HT1197).	flavokawain A	13-26	tumor protein p53	Homo sapiens	58-61	
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	cyclin dependent kinase 1	Homo sapiens	54-58	
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	myelin transcription factor 1	Homo sapiens	79-83	
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	WEE1 G2 checkpoint kinase	Homo sapiens	88-92	
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	cyclin B1	Homo sapiens	105-114	
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	cyclin dependent kinase 1	Homo sapiens	147-151	
19138991-8	2008	Suppression of p53 expression by small interfering RNA in RT4 cells restored Cdc25C expression and down-regulated p21/WAF1 expression, which allowed Cdc25C and CDK1 activation, which then led to a G(2)-M arrest and an enhanced growth-inhibitory effect by flavokawain A.	flavokawain A	255-268	tumor protein p53	Homo sapiens	15-18	
19138991-9	2008	Consistently, flavokawain A also caused a pronounced CDK1 activation and G(2)-M arrest in p53 knockout but not in p53 wild-type HCT116 cells.	flavokawain A	14-27	cyclin dependent kinase 1	Homo sapiens	53-57	
19138991-9	2008	Consistently, flavokawain A also caused a pronounced CDK1 activation and G(2)-M arrest in p53 knockout but not in p53 wild-type HCT116 cells.	flavokawain A	14-27	tumor protein p53	Homo sapiens	90-93	
19138991-10	2008	This selectivity of flavokawain A for inducing a G(2)-M arrest in p53-defective cells deserves further investigation as a new mechanism for the prevention and treatment of bladder cancer.	flavokawain A	20-33	tumor protein p53	Homo sapiens	66-69