Heme

cytochrome P450 family 17 subfamily A member 1 ; Homo sapiens







17 Article(s)
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1 30885648 Design and synthesis of novel steroidal imidazoles as dual inhibitors of AR/CYP17 for the treatment of prostate cancer. 2019 Oct 1
2 29283561 Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202. 2018 Feb 6 1
3 29718108 The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro. 2018 Oct 1 1
4 27566228 Structural insights into the function of steroidogenic cytochrome P450 17A1. 2017 Feb 5 1
5 28373265 Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. 2017 Jun 2
6 27002602 Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling. 2016 Aug 1
7 25650406 Partial deficiency of 17α-hydroxylase/17,20-lyase caused by a novel missense mutation in the canonical cytochrome heme-interacting motif. 2015 May 1
8 24328388 Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17. 2014 Jan 14 1
9 24971814 Novel oxazolinyl derivatives of pregna-5,17(20)-diene as 17α-hydroxylase/17,20-lyase (CYP17A1) inhibitors. 2014 Oct 1
10 21446712 Why human cytochrome P450c21 is a progesterone 21-hydroxylase. 2011 May 17 2
11 19454579 Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene. 2009 Aug 1
12 16176874 Novel mutation of the CYP17 gene in two unrelated patients with combined 17alpha-hydroxylase/17,20-lyase deficiency: demonstration of absent enzyme activity by expressing the mutant CYP17 gene and by three-dimensional modeling. 2005 Nov 5
13 12773039 Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy. 2003 Jun 5 1
14 11243732 Mutation of proline 409 to arginine in the meander region of cytochrome p450c17 causes severe 17 alpha-hydroxylase deficiency. 2001 Mar 1
15 9703423 Identification of a novel splicing mutation and 1-bp deletion in the 17alpha-hydroxylase gene of Japanese patients with 17alpha-hydroxylase deficiency. 1998 Jun 1
16 9177409 A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency. 1997 Jun 1
17 22217842 Molecular basis of 17α-hydroxylase/17,20-lyase deficiency. 1992 Dec 2