Title : Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene.

Pub. Date : 2009 Aug

PMID : 19454579






1 Functional Relationships(s)
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1 Computer-based three-dimensional model analysis of CYP17A1 using CYP2B4 as template showed that three of the mutations had no direct effect on the active center, whereas one affects the heme coordination. Heme cytochrome P450 family 17 subfamily A member 1 Homo sapiens