Title : Mutation of proline 409 to arginine in the meander region of cytochrome p450c17 causes severe 17 alpha-hydroxylase deficiency.

Pub. Date : 2001 Mar

PMID : 11243732






1 Functional Relationships(s)
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1 The proline residue probably causes a turn in the meander region of P450c17, and we hypothesize, by comparison to homologous proteins, that the change in the protein conformation may abolish heme incorporation or may prevent P450c17 from interacting with electron donors. Heme cytochrome P450 family 17 subfamily A member 1 Homo sapiens