Title : Design and synthesis of novel steroidal imidazoles as dual inhibitors of AR/CYP17 for the treatment of prostate cancer.

Pub. Date : 2019 Oct

PMID : 30885648






1 Functional Relationships(s)
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1 Furthermore, the docking results of 13a revealed that the oxygen atom at the position of C-3 connected to the heme of CYP17, which may be helpful for its satisfactory dual-target inhibition. Heme cytochrome P450 family 17 subfamily A member 1 Homo sapiens