2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

phosphatase and tensin homolog ; Homo sapiens







43 Article(s)
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1 32762281 MiR-17-5p inhibits cerebral hypoxia/reoxygenationinjury by targeting PTEN through regulation of PI3K/AKT/mTOR signaling pathway. 2022 Feb 2
2 34697781 Jolkinolide B attenuates laryngeal cancer cell growth and induces apoptosis via PTEN/PI3K/Akt signaling pathway. 2021 Sep 1
3 31204917 [Bmi-1-siRNA Regulates the Proliferation of K562 Leukemia Cells in vitro and in vivo by PTEN/pAKT Pathway]. 2019 Jun 2
4 30612403 [PRDM1 expression and its relationship with PI3K/AKT pathway activation in extranodal NK/T cell lymphoma-nasal type]. 2018 Dec 14 1
5 27746366 MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway. 2017 Jan 5 1
6 28401302 Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway. 2017 Aug 2
7 28442995 MicroRNA-182 Regulates Neurite Outgrowth Involving the PTEN/AKT Pathway. 2017 1
8 28766684 Epigallocatechin-3-gallate promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells via PTEN. 2017 Sep 2
9 26482612 MicroRNA-221 targets PTEN to reduce the sensitivity of cervical cancer cells to gefitinib through the PI3K/Akt signaling pathway. 2016 Mar 1
10 26568302 EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loop. 2016 Jun 30 2
11 27699665 miR-222 induces Adriamycin resistance in breast cancer through PTEN/Akt/p27kip1 pathway. 2016 Nov 1
12 27822469 PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells. 2016 1
13 25510413 Survival-apoptosis associated signaling in GNE myopathy-cultured myoblasts. 2015 2
14 26000878 Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation. 2015 2
15 26078825 Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel. 2015 1
16 24603487 PTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemia. 2014 1
17 25531381 [The anti-apoptotic effect of cytoplasmic alpha-fetoprotein in hepatoma cells induced by all-trans retinoic acid involves activation of the PI3K/AKT signaling pathway]. 2014 Nov 1
18 23372675 MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma. 2013 1
19 23973711 Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathway. 2013 Sep 20 1
20 24143235 Differential activation of Wnt-β-catenin pathway in triple negative breast cancer increases MMP7 in a PTEN dependent manner. 2013 1
21 22710837 PTEN activation sensitizes breast cancer to PI3-kinase inhibitor through the β-catenin signaling pathway. 2012 Sep 4
22 20473866 Alpha-fetoprotein: a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines. 2011 Feb 1 1
23 20664988 PTEN sensitizes MDA-MB-468 cells to inhibition of MEK/Erk signaling for the blockade of cell proliferation. 2010 Sep 4
24 20712893 XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. 2010 Aug 16 2
25 18726116 Loss of PTEN function may account for reduced proliferation pathway sensitivity to LY294002 in human prostate and bladder cancer cells. 2009 Feb 4
26 19347904 Rapamycin selectively reduces the association of transcripts containing complex 5' UTRs with ribosomes in C4-2B prostate cancer cells. 2009 Jun 1 1
27 19472407 A gene-alteration profile of human lung cancer cell lines. 2009 Aug 1
28 18307411 The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. 2008 Jun 1 1
29 18676830 An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. 2008 Aug 1 1
30 18676851 Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis. 2008 Aug 1 1
31 16842970 Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines. 2007 Jan 4
32 15735908 PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. 2005 Feb 1
33 15809062 Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells. 2005 May 13 1
34 16154532 PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2. 2005 Nov 4 2
35 15067356 Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. 2004 May 1
36 15367412 Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway. 2004 Oct 2
37 12517803 PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. 2003 Jan 1 1
38 12546364 Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. 2003 Jan 1
39 12839945 PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. 2003 Jul 1 1
40 11830512 Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. 2002 Feb 1 1
41 11687610 Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. 2001 Nov 6 1
42 10749120 Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. 2000 Mar 15 1
43 9860981 PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. 1998 Dec 22 1