PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18307411-9 2008 Nedd4 expression was also decreased by a PI3K (phosphoinositide 3-kinase) inhibitor, LY294002, suggesting that the regulation is dependent on the phosphatase-kinase activity of the PTEN-PI3K/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 85-93 phosphatase and tensin homolog Homo sapiens 181-185 15809062-9 2005 In addition, the PI3 kinase inhibitor, LY294002, upregulates IGFBP-3 expression but downregulates IGF-I and IGF-II, indicating that PTEN controls IGFBP-3 and IGFs by an Akt-dependent pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 phosphatase and tensin homolog Homo sapiens 132-136 16154532-4 2005 The PTEN-induced decrease in IGFBP-2 expression could be mimicked with the PI3-kinase inhibitor LY294002, indicating that the lipid phosphatase activity of PTEN is responsible for the observed effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 96-104 phosphatase and tensin homolog Homo sapiens 4-8 16154532-4 2005 The PTEN-induced decrease in IGFBP-2 expression could be mimicked with the PI3-kinase inhibitor LY294002, indicating that the lipid phosphatase activity of PTEN is responsible for the observed effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 96-104 phosphatase and tensin homolog Homo sapiens 156-160 16842970-7 2007 In the PTEN-positive prostate-derived cell lines PNT2, PNT1a and P4E6, PI3K inhibition by LY294002 caused rapid dephosphorylation of PKB at ser473 (T(1/2)<2 min), leading to its inactivation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 phosphatase and tensin homolog Homo sapiens 7-11 16842970-8 2007 In the PTEN-null line LNCaP, LY294002-induced PKB dephosphorylation was much slower (T(1/2)>20 min), but in PC3 cells (also PTEN-null) it was only slightly slower than in PTEN-positive cells (T(1/2)=3 min). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 phosphatase and tensin homolog Homo sapiens 7-11 16842970-8 2007 In the PTEN-null line LNCaP, LY294002-induced PKB dephosphorylation was much slower (T(1/2)>20 min), but in PC3 cells (also PTEN-null) it was only slightly slower than in PTEN-positive cells (T(1/2)=3 min). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 phosphatase and tensin homolog Homo sapiens 127-131 16842970-8 2007 In the PTEN-null line LNCaP, LY294002-induced PKB dephosphorylation was much slower (T(1/2)>20 min), but in PC3 cells (also PTEN-null) it was only slightly slower than in PTEN-positive cells (T(1/2)=3 min). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 phosphatase and tensin homolog Homo sapiens 127-131 12517803-6 2003 Treatment of U87MG cells with LY294002, a PI3K inhibitor, or cotransfection with a vector expressing wild-type PTEN decreased VEGF promoter activity using reporters containing either 1.5 kb of the promoter or a fragment extending from -88 to +54 bp. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 30-38 phosphatase and tensin homolog Homo sapiens 111-115 15367412-6 2004 The PTEN-negative cell line displayed greater sensitivity to the growth inhibitory effects of the PI3K inhibitor, LY294002 and rapamycin, an inhibitor of the PI3K/Akt downstream mediator mTOR, compared with the PTEN-positive cell lines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 114-122 phosphatase and tensin homolog Homo sapiens 4-8 15367412-8 2004 These reduced PTEN cells demonstrated an increased sensitivity to the anti-proliferative effects induced by LY294002 and rapamycin compared with the parental cells, which corresponded to alterations in cell cycle response. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 108-116 phosphatase and tensin homolog Homo sapiens 14-18 15735908-4 2005 The effects of LY294002, a biochemical inhibitor of PI3-kinase, on the response to radiation were examined in the PTEN mutant glioma cell line U251 MG. Low doses of LY294002 sensitized U251 MG to clinically relevant doses of radiation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 165-173 phosphatase and tensin homolog Homo sapiens 114-118 15067356-11 2004 Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 phosphatase and tensin homolog Homo sapiens 123-127 12839945-4 2003 PTEN and LY294002 induced p53 activity in human brain endothelial cells, suggesting that PTEN and PI3K pathways can suppress the progression of cancer through direct actions on tumor and endothelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 phosphatase and tensin homolog Homo sapiens 89-93 12546364-8 2003 The LY294002 significantly augmented the cytotoxicity induced by etoposide in PTEN-deficient cells, but not in PTEN-wt cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 4-12 phosphatase and tensin homolog Homo sapiens 78-82 11830512-3 2002 Using LNCaP prostate cancer cells as an experimental paradigm of FAS-overexpressing PTEN-null cancer cells, we demonstrate that LY294002, an inhibitor of the PI3k pathway causes a dramatic decrease in FAS protein expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 128-136 phosphatase and tensin homolog Homo sapiens 84-88 10749120-4 2000 LY294002 and rapamycin also inhibit growth factor- and mitogen-induced secretion of vascular endothelial growth factor, the product of a known HIF-1 target gene, thus linking the PI3K/PTEN/AKT/FRAP pathway, HIF-1, and tumor angiogenesis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 phosphatase and tensin homolog Homo sapiens 184-188 11687610-4 2001 The changes we see are similar to those observed after treatment with LY294002, an inhibitor of phosphatidylinositol 3-OH kinase, fully consistent with the model that PTEN antagonizes phosphatidylinositol 3-OH kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 70-78 phosphatase and tensin homolog Homo sapiens 167-171 34697781-11 2021 Western blotting results showed that JB and LY294002 treatment significantly inhibited the levels of Bcl-2, p-PI3K, and p-Akt while the levels of Bax, cleaved caspase-3, and PTEN protein significantly increased. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 phosphatase and tensin homolog Homo sapiens 174-178 9860981-8 1998 In addition, the effect of PTEN on p27(KIP1) and the cell cycle can be mimicked by treatment of U87MG cells with LY294002, a selective inhibitor of PI 3-kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 113-121 phosphatase and tensin homolog Homo sapiens 27-31 32762281-8 2022 Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 phosphatase and tensin homolog Homo sapiens 229-233 32762281-8 2022 Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 phosphatase and tensin homolog Homo sapiens 337-341 31204917-6 2019 While the pAKT expression in Bmi-1 gene-silenced group was significantly reduced; after the K562 cells were treated with LY294002 (an inhibitor of pAKT), the pAKT expression colony-forming and tumor forming abilities were reduced in comparison with untreated K562 cells; after the K562-S1 cells were treated with Bpv (an inhibitor of PTEN), the PTEN expression decreased, while the pAKT expression, colony forming and tumor-forming abilities were restored. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 121-129 phosphatase and tensin homolog Homo sapiens 334-338 31204917-6 2019 While the pAKT expression in Bmi-1 gene-silenced group was significantly reduced; after the K562 cells were treated with LY294002 (an inhibitor of pAKT), the pAKT expression colony-forming and tumor forming abilities were reduced in comparison with untreated K562 cells; after the K562-S1 cells were treated with Bpv (an inhibitor of PTEN), the PTEN expression decreased, while the pAKT expression, colony forming and tumor-forming abilities were restored. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 121-129 phosphatase and tensin homolog Homo sapiens 345-349 30612403-7 2018 In addition, LY294002, a PI3K/AKT pathway inhibitor, increased PRDM1 and PTEN expression in a dose dependent manner in YT cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 phosphatase and tensin homolog Homo sapiens 73-77 27746366-12 2017 For further validation, results of the present study also demonstrated that PTEN/Akt/FOXO1 signaling was responsible for the ADR-resistance of breast cancer cells since LY294002, an inhibitor of Akt signaling, partially increased the sensitivity of MCF-7/S cells to ADR. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 169-177 phosphatase and tensin homolog Homo sapiens 76-80 28442995-7 2017 Inhibition of AKT activity with the PI3-K inhibitor LY294002 could downregulate AKT and PTEN phosphorylation and suppress axon outgrowth. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 phosphatase and tensin homolog Homo sapiens 88-92 28766684-7 2017 Moreover, the induction of PTEN attenuated the Akt phosphorylation levels, pretreatment of PI3K inhibitor LY294002 in NB4 cells, significantly augmented the cell differentiation and increased the expression of PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 phosphatase and tensin homolog Homo sapiens 27-31 28766684-7 2017 Moreover, the induction of PTEN attenuated the Akt phosphorylation levels, pretreatment of PI3K inhibitor LY294002 in NB4 cells, significantly augmented the cell differentiation and increased the expression of PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 phosphatase and tensin homolog Homo sapiens 210-214 28401302-13 2017 In addition, the growth of U251 glioma xenografts treated with the combination of Ad-PTEN and LY294002 was significantly inhibited compared with those treated with Ad-PTEN or LY294002 alone. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 94-102 phosphatase and tensin homolog Homo sapiens 167-171 28401302-13 2017 In addition, the growth of U251 glioma xenografts treated with the combination of Ad-PTEN and LY294002 was significantly inhibited compared with those treated with Ad-PTEN or LY294002 alone. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 175-183 phosphatase and tensin homolog Homo sapiens 85-89 24603487-6 2014 PTEN and p-Akt downregulation could be abrogated by both the PI3K inhibitor LY294002 and the mTOR inhibitor rapamycin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 phosphatase and tensin homolog Homo sapiens 0-4 27822469-7 2016 Furthermore, using the PI3K/AKT pathway blocker LY294002, we confirmed that the PI3K/AKT pathway was involved in mediating these effects of PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 phosphatase and tensin homolog Homo sapiens 140-144 26000878-10 2015 Correspondingly, treatment with LY294002, a phosphatidylinositol-3-kinase inhibitor, mimicked PTEN overexpression effect in KYSE-150/RR cells, further suggesting a role for the Akt/GSK-3beta/Snail signaling in effects mediated through PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 32-40 phosphatase and tensin homolog Homo sapiens 94-98 26000878-10 2015 Correspondingly, treatment with LY294002, a phosphatidylinositol-3-kinase inhibitor, mimicked PTEN overexpression effect in KYSE-150/RR cells, further suggesting a role for the Akt/GSK-3beta/Snail signaling in effects mediated through PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 32-40 phosphatase and tensin homolog Homo sapiens 235-239 25531381-5 2014 PTEN and AFP co-localized in the cytoplasm, and co-IP indicated that AFP interacts with PTEN in BEL-7402 cells.RNAi knockdown of AFP expression led to reduced growth of BEL-7402 cells.BEL-7402 cells transfected with AFP-short interfering (si)RNA vectors showed enhanced sensitivity to ATRA and reduced expression of pAKT(Ser473) and Src; Ly294002 reduced the role of AFP in stimulating expression of pAKT(Ser473) and Src. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 338-346 phosphatase and tensin homolog Homo sapiens 88-92 27699665-10 2016 Importantly, Adr resistance induced by miR-222 overexpression through PTEN/Akt/p27 was completely blocked by LY294002, an Akt inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 109-117 phosphatase and tensin homolog Homo sapiens 70-74 26568302-10 2016 The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 24-32 phosphatase and tensin homolog Homo sapiens 149-153 26568302-10 2016 The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 24-32 phosphatase and tensin homolog Homo sapiens 187-191 26482612-6 2016 Importantly, gefitinib sensitivity was decreased by the upregulation of miR-221, which was blocked by pcDNA-PTEN co-transfection or by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 186-194 phosphatase and tensin homolog Homo sapiens 108-112 25510413-6 2015 In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 phosphatase and tensin homolog Homo sapiens 64-68 25510413-6 2015 In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 phosphatase and tensin homolog Homo sapiens 174-178 26078825-7 2015 The specific PTEN and PI3K inhibitors, BPV(pic) and LY294002, influence ENaC activity in AGEs-pretreated A6 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 phosphatase and tensin homolog Homo sapiens 13-17 24143235-6 2013 Genetic or pharmacological attenuation of beta-catenin by SiRNA or WP modulators (XAV939 and sulindac sulfide) and pharmacological mimicking of PTEN following LY294002 treatment downregulated MMP7 levels as well as enzymatic function of the secreted MMP7 in MMP7 positive PTEN-null TNBC cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 159-167 phosphatase and tensin homolog Homo sapiens 272-276 23372675-12 2013 Furthermore, introduction of PTEN cDNA lacking 3"-UTR or PI3K inhibitor LY294002 abrogated miR-221-induced cisplatin resistance. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 72-80 phosphatase and tensin homolog Homo sapiens 29-33 23973711-10 2013 The Akt inhibitor, LY294002, augmented the effect of simvastatin on PTEN wild-type TNBC cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 phosphatase and tensin homolog Homo sapiens 68-72 20473866-6 2011 The inhibition of PI3K signaling by LY 294002 was simultaneously reversed by transfection, accompanied by diminution of all trans-retinoic acid-induced upregulation of PTEN and enhancement of cell growth. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-45 phosphatase and tensin homolog Homo sapiens 168-172 22710837-5 2012 Herein, we show that AD-PTEN significantly enhanced the sensitization of breast cancer cells to LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 120-128 phosphatase and tensin homolog Homo sapiens 33-40 22710837-7 2012 In addition, treatment of AD-PTEN-transfected cells with LY294002 resulted in significantly reduced cell viability and invasion ability compared to single LY294002 treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 57-65 phosphatase and tensin homolog Homo sapiens 26-33 22710837-7 2012 In addition, treatment of AD-PTEN-transfected cells with LY294002 resulted in significantly reduced cell viability and invasion ability compared to single LY294002 treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 179-187 phosphatase and tensin homolog Homo sapiens 26-33 22710837-10 2012 Our results indicate that AD-PTEN sensitization of breast cancer to LY294002 is achieved by increased GSK-3beta activity, thus resulting in inhibition of the beta-catenin signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 80-88 phosphatase and tensin homolog Homo sapiens 38-45 20664988-4 2010 When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a >60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 38-46 phosphatase and tensin homolog Homo sapiens 153-157 20664988-4 2010 When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a >60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 38-46 phosphatase and tensin homolog Homo sapiens 238-242 20664988-4 2010 When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a >60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 phosphatase and tensin homolog Homo sapiens 153-157 20664988-4 2010 When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a >60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 phosphatase and tensin homolog Homo sapiens 238-242 20712893-11 2010 Although each TGF-beta isoform decreased PTEN content in a XIAP- and a Smad-dependent manner, decrease of PTEN levels in response to only one isoform, TGF-beta3, was blocked by PI3-K inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 193-201 phosphatase and tensin homolog Homo sapiens 41-45 20712893-11 2010 Although each TGF-beta isoform decreased PTEN content in a XIAP- and a Smad-dependent manner, decrease of PTEN levels in response to only one isoform, TGF-beta3, was blocked by PI3-K inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 193-201 phosphatase and tensin homolog Homo sapiens 106-110 19347904-8 2009 Although LY294002 and similar inhibitors are effective at blocking prostate cancer cell growth, they act upstream of AKT and PTEN and cancer cells can find a way to bypass this inhibition. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 phosphatase and tensin homolog Homo sapiens 125-129 19472407-7 2009 Cells with single activation of ERBB2, PTEN, or MET signaling showed greater sensitivity to cell-growth inhibition induced by erlotinib, LY294002, and PHA665752, respectively, than did cells featuring simultaneous activation of these pathways, underlining the need for combined therapeutic strategies in targeted cancer treatments. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 137-145 phosphatase and tensin homolog Homo sapiens 39-43 18726116-0 2009 Loss of PTEN function may account for reduced proliferation pathway sensitivity to LY294002 in human prostate and bladder cancer cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 phosphatase and tensin homolog Homo sapiens 8-12 18726116-6 2009 RESULTS: After 6 weeks, proliferation pathway sensitivity to LY294002 was reduced in cells expressing PTEN, but not in PTEN-null cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 61-69 phosphatase and tensin homolog Homo sapiens 102-106 18726116-8 2009 Stable PTEN expression in PTEN-null UM-UC-3 cells increased serum-induced ERK activation and sensitivity to PD98059-treatment, and reduced sensitivity to LY294002 after 6 weeks of exposure. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 154-162 phosphatase and tensin homolog Homo sapiens 7-11 18726116-8 2009 Stable PTEN expression in PTEN-null UM-UC-3 cells increased serum-induced ERK activation and sensitivity to PD98059-treatment, and reduced sensitivity to LY294002 after 6 weeks of exposure. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 154-162 phosphatase and tensin homolog Homo sapiens 26-30 18676830-9 2008 PTEN loss rendered cells significantly more sensitive to growth inhibition by the PI3K inhibitor LY294002 than did PIK3CA mutations. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 97-105 phosphatase and tensin homolog Homo sapiens 0-4 18676851-3 2008 Here, we report that inhibition of PI3K by LY294002 broadly sensitizes wild-type and mutant PTEN glioblastoma cells to both death receptor- and chemotherapy-induced apoptosis, whereas mammalian target of rapamycin (mTOR) inhibition is not sufficient to restore apoptosis sensitivity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 phosphatase and tensin homolog Homo sapiens 92-96