Pub. Date : 2012 Sep
PMID : 22710837
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein, we show that AD-PTEN significantly enhanced the sensitization of breast cancer cells to LY294002. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | phosphatase and tensin homolog | Homo sapiens |
| 2 | In addition, treatment of AD-PTEN-transfected cells with LY294002 resulted in significantly reduced cell viability and invasion ability compared to single LY294002 treatment. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | phosphatase and tensin homolog | Homo sapiens |
| 3 | In addition, treatment of AD-PTEN-transfected cells with LY294002 resulted in significantly reduced cell viability and invasion ability compared to single LY294002 treatment. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | phosphatase and tensin homolog | Homo sapiens |
| 4 | Our results indicate that AD-PTEN sensitization of breast cancer to LY294002 is achieved by increased GSK-3beta activity, thus resulting in inhibition of the beta-catenin signaling pathway. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | phosphatase and tensin homolog | Homo sapiens |