Title : Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis.

Pub. Date : 2008 Aug 1

PMID : 18676851






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we report that inhibition of PI3K by LY294002 broadly sensitizes wild-type and mutant PTEN glioblastoma cells to both death receptor- and chemotherapy-induced apoptosis, whereas mammalian target of rapamycin (mTOR) inhibition is not sufficient to restore apoptosis sensitivity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one phosphatase and tensin homolog Homo sapiens