Cysteine

phosphatase and tensin homolog ; Homo sapiens







22 Article(s)
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1 35216667 Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma. 2022 Apr 7 1
2 32413744 Redox regulation of tumor suppressor PTEN in cell signaling. 2020 Jul 1
3 30959964 Annexin A2 Regulates AKT Upon H₂O₂-Dependent Signaling Activation in Cancer Cells. 2019 Apr 7 3
4 29550515 15-Deoxy-Δ12,14-prostaglandin J2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136. 2018 Jun 28 4
5 25446078 Endogenous S-sulfhydration of PTEN helps protect against modification by nitric oxide. 2015 Jan 2 2
6 25637034 Assay of the redox state of the tumor suppressor PTEN by mobility shift. 2015 May 3
7 24759986 PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation. 2014 Jul 1
8 25378175 Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. 2014 Nov 5 2
9 23872024 Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis. 2013 Dec 3
10 22095074 Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target. 2012 Feb 1
11 21953448 Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Cζ/λ (PKCζ/λ) in 3T3l1 adipocytes. 2011 Nov 18 1
12 20685300 Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN. 2010 Sep 2
13 21067594 NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. 2010 Nov 10 2
14 17324556 PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation. 2007 Jul 1
15 17941496 Association of multiple vertebral hemangiomas and severe paraparesis in a patient with a PTEN hamartoma tumor syndrome. Case report. 2007 Oct 1
16 15890001 Functions and mechanisms of redox regulation of cysteine-based phosphatases. 2005 May-Jun 1
17 15967877 Redox regulation of PTEN by S-nitrosothiols. 2005 Sep 1
18 15017976 Redox regulation of PTEN and protein tyrosine phosphatases in H(2)O(2) mediated cell signaling. 2004 Feb 27 1
19 15313215 Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity. 2004 Sep 15 4
20 15534200 Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. 2004 Nov 23 1
21 11916965 Reversible inactivation of the tumor suppressor PTEN by H2O2. 2002 Jun 7 3
22 12549040 [Mutation analysis of the tumor suppressor gene PTEN/MMAC1/TEP1 in human hepatocellular carcinoma]. 2000 Sep 1