Title : PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation.

Pub. Date : 2014 Jul

PMID : 24759986






1 Functional Relationships(s)
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1 Hence, we hypothesize that zinc signals affect the IL-2-dependent PI3K/Akt pathway by inhibiting the negative regulator PTEN through binding with a sub-nanomolar affinity to cysteine residues that are essential for its catalytic activity. Cysteine phosphatase and tensin homolog Homo sapiens