| 1 |
35134645 | Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment. | 2022 Mar |
1 |
| 2 |
33732767 | CENP-C Phosphorylation by CDK1 in vitro. | 2021 Jan 5 |
1 |
| 3 |
33931002 | Exploring multi-target inhibitors using in silico approach targeting cell cycle dysregulator-CDK proteins. | 2021 Apr 30 |
2 |
| 4 |
35155443 | Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos. | 2021 |
1 |
| 5 |
31241436 | Inhibitors of Cyclin-Dependent Kinase 1/2 for Anticancer Treatment. | 2020 |
1 |
| 6 |
32200332 | Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. | 2020 May |
1 |
| 7 |
32415712 | Development of CDK2 and CDK5 Dual Degrader TMX-2172. | 2020 Aug 10 |
1 |
| 8 |
30472117 | Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. | 2019 Jan 17 |
1 |
| 9 |
30481564 | Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. | 2019 Feb 28 |
1 |
| 10 |
30508677 | Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs. | 2019 Jan |
1 |
| 11 |
30449668 | Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells. | 2018 Dec 3 |
2 |
| 12 |
28005359 | Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. | 2017 Mar 9 |
1 |
| 13 |
25864384 | CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. | 2015 Apr 13 |
1 |
| 14 |
26131711 | Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. | 2015 |
1 |
| 15 |
26207228 | Roscovitine in cancer and other diseases. | 2015 Jun |
1 |
| 16 |
26670043 | CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair. | 2015 Dec 15 |
2 |
| 17 |
24746669 | Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. | 2014 Apr 28 |
1 |
| 18 |
23525902 | Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle. | 2013 Jul 15 |
2 |
| 19 |
23954627 | A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes. | 2013 Sep 17 |
1 |
| 20 |
22622012 | Pharmacophore identification, docking and "in silico" screening for novel CDK1 inhibitors. | 2012 Jul |
2 |
| 21 |
20808790 | Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. | 2010 Aug 23 |
2 |
| 22 |
18232654 | Pyrrolo[2,3-a]carbazoles as potential cyclin dependent kinase 1 (CDK1) Inhibitors. Synthesis, biological evaluation, and binding mode through docking simulations. | 2008 Feb 28 |
1 |
| 23 |
18234856 | Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. | 2008 Feb 5 |
1 |
| 24 |
17070718 | Regulation of telomere elongation by the cyclin-dependent kinase CDK1. | 2006 Nov 3 |
1 |
| 25 |
15702922 | Homology model of the CDK1/cyclin B complex. | 2005 Apr |
1 |
| 26 |
15853645 | Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases. | 2005 |
1 |
| 27 |
14695817 | Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones. | 2004 Jan 1 |
1 |
| 28 |
15047157 | Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. | 2004 Apr 23 |
2 |
| 29 |
15239650 | N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2. | 2004 Jul 15 |
4 |
| 30 |
15474478 | Molecular models of cyclin-dependent kinase 1 complexed with inhibitors. | 2004 Nov 12 |
2 |
| 31 |
12678910 | Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors. | 2003 Jan |
1 |
| 32 |
14550307 | SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2. | 2003 Oct 24 |
1 |
| 33 |
12054639 | Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol. | 2002 Apr 26 |
1 |
| 34 |
12139449 | Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. | 2002 Aug 1 |
3 |
| 35 |
12154027 | Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat. | 2002 Aug 1 |
1 |
| 36 |
12244298 | Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor. | 2002 Oct |
1 |
| 37 |
12372407 | Molecular model of cyclin-dependent kinase 5 complexed with roscovitine. | 2002 Oct 11 |
1 |
| 38 |
11136719 | Chromosome condensation by a human condensin complex in Xenopus egg extracts. | 2001 Feb 23 |
1 |
| 39 |
11394741 | Identification of cylin-dependent kinase 1 inhibitors of a new chemical type by structure-based design and database searching. | 2001 May |
1 |
| 40 |
10788588 | Cell cycle molecular targets in novel anticancer drug discovery. | 2000 Mar |
2 |
| 41 |
10888036 | Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition. | 2000 Feb |
1 |
| 42 |
10956187 | Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. | 2000 Jul 27 |
1 |
| 43 |
11029659 | Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. | 2000 Oct |
3 |
| 44 |
9515786 | T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21. | 1998 Mar 15 |
1 |
| 45 |
9030780 | Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. | 1997 Jan 15 |
1 |
| 46 |
9552418 | Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14. | 1997 |
2 |
| 47 |
7592534 | Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract. | 1995 Apr |
1 |
| 48 |
7876309 | Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. | 1995 Mar |
1 |
| 49 |
8397207 | Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. | 1993 Sep 25 |
1 |
| 50 |
8441405 | Mechanisms of p34cdc2 regulation. | 1993 Mar |
6 |