Title : Molecular model of cyclin-dependent kinase 5 complexed with roscovitine.

Pub. Date : 2002 Oct 11

PMID : 12372407






1 Functional Relationships(s)
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1 The structural model indicates that roscovitine strongly binds to the ATP-binding pocket of CDK5 and structural comparison of the CDK2-roscovitine complex correlates the structural differences with differences in inhibition of these CDKs by this inhibitor. Adenosine Triphosphate cyclin dependent kinase 1 Homo sapiens