Title : Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.

Pub. Date : 2017 Mar 9

PMID : 28005359






1 Functional Relationships(s)
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1 6-Substituents that favor competitive inhibition at the ATP binding site of CDK2 were identified and typically exhibited 10-80-fold greater inhibition of CDK2 compared to CDK1. Adenosine Triphosphate cyclin dependent kinase 1 Homo sapiens