Glutathione

ATP binding cassette subfamily B member 1 ; Homo sapiens







78 Article(s)
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1 35080351 GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators. 2022 Jan 26 14
2 35173543 High Expression of G6PD Increases Doxorubicin Resistance in Triple Negative Breast Cancer Cells by Maintaining GSH Level. 2022 1
3 34842266 Lenvatinib and Cu2-xS nanocrystals co-encapsulated in poly(D,L-lactide-co-glycolide) for synergistic chemo-photothermal therapy against advanced hepatocellular carcinoma. 2021 Dec 15 2
4 32377003 Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1. 2020 May 6 5
5 30726737 A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. 2019 Feb 5 2
6 30806880 Exposure of Cultured Astrocytes to Menadione Triggers Rapid Radical Formation, Glutathione Oxidation and Mrp1-Mediated Export of Glutathione Disulfide. 2019 May 1
7 31268744 Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1). 2019 Oct 3
8 31302132 MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells. 2019 Oct 11
9 27738951 Tumor Targeting Synergistic Drug Delivery by Self-Assembled Hybrid Nanovesicles to Overcome Drug Resistance. 2017 Jan 2
10 27855620 MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion. 2017 1
11 28303926 Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles. 2017 Mar 17 1
12 27572418 Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase. 2016 Oct 1
13 24050699 Targeting multidrug resistance protein 1 (MRP1, ABCC1): past, present, and future. 2014 1
14 24146141 Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1. 2014 Jan 2
15 24875445 Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux. 2014 Aug 1 8
16 25281745 Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. 2014 Nov 7 1
17 23341120 The antiretroviral protease inhibitor ritonavir accelerates glutathione export from cultured primary astrocytes. 2013 Apr 1
18 23542460 Arsenate accumulation and arsenate-induced glutathione export in astrocyte-rich primary cultures. 2013 Jun 1
19 23800365 Formaldehyde in brain: an overlooked player in neurodegeneration? 2013 Oct 1
20 24013781 Nuclear multidrug-resistance related protein 1 contributes to multidrug-resistance of mucoepidermoid carcinoma mainly via regulating multidrug-resistance protein 1: a human mucoepidermoid carcinoma cells model and Spearman's rank correlation analysis. 2013 1
21 24382184 Modulation of multidrug resistance P-glycoprotein activity by antiemetic compounds in human doxorubicin-resistant sarcoma cells (MES-SA/Dx-5): implications on cancer therapy. 2013 Oct-Dec 4
22 22017299 The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes. 2012 Jan 3
23 22197475 Arsenic-glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs). 2012 Mar 1
24 22464990 Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1. 2012 Jun 2
25 21166805 Formaldehyde stimulates Mrp1-mediated glutathione deprivation of cultured astrocytes. 2011 Feb 2
26 21634011 Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1. 2011 Aug 1 5
27 21925487 Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1). 2011 Nov 15 5
28 20487633 Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy. 2010 Apr-Jun 4
29 20691599 Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1. 2010 Sep 1 5
30 19398503 Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1). 2009 Jul 5
31 19409044 P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin. 2009 Apr 1
32 18556457 Elevated GSH level increases cadmium resistance through down-regulation of Sp1-dependent expression of the cadmium transporter ZIP8. 2008 Sep 2
33 18768387 Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport. 2008 Dec 1
34 17187268 Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). 2007 Feb 2
35 18059532 A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax. 2007 Dec 1
36 16415113 Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity. 2006 Apr 1
37 16434618 Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. 2006 Apr 4
38 16565074 Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1). 2006 May 19 1
39 16769721 A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells. 2006 Aug 18 2
40 16784241 Modulation of nitrated lipid signaling by multidrug resistance protein 1 (MRP1): glutathione conjugation and MRP1-mediated efflux inhibit nitrolinoleic acid-induced, PPARgamma-dependent transcription activation. 2006 Jun 27 2
41 16820223 Transport of glutathione and glutathione conjugates by MRP1. 2006 Aug 6
42 16861249 A functional role of intracellular loops of human multidrug resistance protein 1. 2006 Sep 1
43 15617835 Potentiation by alpha-tocopheryl succinate of the etoposide response in multidrug resistance protein 1-expressing glioblastoma cells. 2005 Jan 20 6
44 16041243 Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1). 2005 Sep 3
45 16098482 MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate). 2005 Oct 1 9
46 16105987 Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites. 2005 Nov 1
47 16399362 Multidrug resistance protein 1-mediated export of glutathione and glutathione disulfide from brain astrocytes. 2005 1
48 12424247 Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione. 2003 Jan 31 1
49 12485947 Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). 2003 Jan 9
50 12538817 Structural requirements for functional interaction of glutathione tripeptide analogs with the human multidrug resistance protein 1 (MRP1). 2003 Feb 10