Pub. Date : 2019 Oct
PMID : 31302132
11 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | We characterized a novel small molecule modulator that selectively enhanced MRP1-dependent efflux of reduced glutathione (GSH), an endogenous MRP1 substrate. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 2 | We characterized a novel small molecule modulator that selectively enhanced MRP1-dependent efflux of reduced glutathione (GSH), an endogenous MRP1 substrate. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 3 | We characterized a novel small molecule modulator that selectively enhanced MRP1-dependent efflux of reduced glutathione (GSH), an endogenous MRP1 substrate. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 4 | We characterized a novel small molecule modulator that selectively enhanced MRP1-dependent efflux of reduced glutathione (GSH), an endogenous MRP1 substrate. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 5 | Using cell lines expressing high levels of endogenous MRP1 from three difficult to treat cancer types-lung cancer, ovarian cancer and high-risk neuroblastoma-we showed that the MRP1 modulator substantially lowered intracellular GSH levels as a single agent. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 6 | Using cell lines expressing high levels of endogenous MRP1 from three difficult to treat cancer types-lung cancer, ovarian cancer and high-risk neuroblastoma-we showed that the MRP1 modulator substantially lowered intracellular GSH levels as a single agent. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 7 | The effect was on-target, as MRP1 knockdown abolished GSH depletion. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 8 | The MRP1 modulator was synergistic with the GSH synthesis inhibitor buthionine sulfoximine (BSO), with the combination exhausting intracellular GSH, increasing intracellular reactive oxygen species (ROS) and abolishing clonogenic capacity. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 9 | The MRP1 modulator was synergistic with the GSH synthesis inhibitor buthionine sulfoximine (BSO), with the combination exhausting intracellular GSH, increasing intracellular reactive oxygen species (ROS) and abolishing clonogenic capacity. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 10 | GSH-depleting MRP1 modulators may therefore provide an enhanced therapeutic window to treat chemo-resistant MRP1-overexpressing pediatric and adult cancers. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||
| 11 | GSH-depleting MRP1 modulators may therefore provide an enhanced therapeutic window to treat chemo-resistant MRP1-overexpressing pediatric and adult cancers. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens | ||