Title : A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.

Pub. Date : 2006 Aug 18

PMID : 16769721






2 Functional Relationships(s)
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Protein Name
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1 A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. Glutathione ATP binding cassette subfamily B member 1 Homo sapiens
2 The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. CEM-VBL10, CEM-VBL100, and U-2 OS/DX580. Glutathione ATP binding cassette subfamily B member 1 Homo sapiens