Pub. Date : 2006 Apr
PMID : 16434618
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Unlike ABCG2 (breast cancer resistance protein, mitoxantrone-resistant protein), MRP1-mediated MX transport is dependent upon the presence of glutathione or its S-methyl analog. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Together, these data are consistent with the interpretation that MX efflux by MRP1 involves cotransport of MX and glutathione. | Glutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |