67 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
1 | 34978431 | How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen. | 2022 Jan 18 | 1 |
2 | 32556284 | A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation. | 2020 Jun 23 | 1 |
3 | 33260771 | In Silico Structural and Functional Characterization of HtrA Proteins of Leptospira spp.: Possible Implications in Pathogenesis. | 2020 Nov 28 | 1 |
4 | 23195954 | Serine protease activity of calnuc: regulation by Zn2+ and G proteins. | 2013 Jan 18 | 1 |
5 | 21069403 | Expression and characterization of a novel mesophilic protease from metagenomic library derived from Antarctic coastal sediment. | 2011 Jan | 1 |
6 | 21097875 | The catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease action. | 2011 Feb 4 | 1 |
7 | 20071328 | Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D. | 2010 Mar 12 | 1 |
8 | 20236938 | Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. | 2010 May 14 | 1 |
9 | 17950494 | Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue. | 2008 Jun | 1 |
10 | 18714034 | Production of C5a by ASP, a serine protease released from Aeromonas sobria. | 2008 Sep 1 | 1 |
11 | 19053259 | Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1. | 2008 Dec 16 | 2 |
12 | 17428793 | Structural basis of Na+ activation mimicry in murine thrombin. | 2007 Jun 1 | 1 |
13 | 17642517 | The determination of protonation states in proteins. | 2007 Aug | 1 |
14 | 18019535 | Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold. | 2007 Aug 21 | 1 |
15 | 16454727 | Metabolism-directed optimisation of antithrombotics: the prodrug principle. | 2006 | 1 |
16 | 16672239 | Recurrent use of evolutionary importance for functional annotation of proteins based on local structural similarity. | 2006 Jun | 1 |
17 | 15582990 | Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C. | 2005 Mar 4 | 1 |
18 | 15998637 | Thrombin functions through its RGD sequence in a non-canonical conformation. | 2005 Aug 19 | 1 |
19 | 14679197 | Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin. | 2004 Mar 12 | 3 |
20 | 14978285 | Crystal structure of the complex between thrombin and the central "E" region of fibrin. | 2004 Mar 2 | 3 |
21 | 12588872 | Mutations in autolytic loop-2 and at Asp554 of human prothrombin that enhance protein C activation by meizothrombin. | 2003 Apr 25 | 1 |
22 | 12778490 | The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells. | 2003 Jun | 1 |
23 | 12794066 | Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate. | 2003 Aug 22 | 1 |
24 | 12926277 | Synthesis and hydrolysis studies of a peptide containing the reactive triad of serine proteases with an associated linker to a dye on a solid phase support. | 2003 May 7 | 1 |
25 | 13678420 | Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. | 2003 Dec 15 | 3 |
26 | 14654359 | Directed evolution towards protease-resistant hirudin variants. | 2003 Dec | 1 |
27 | 11856753 | Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote intramolecular interactions during glycosaminoglycan binding and thrombin inhibition. | 2002 May 31 | 1 |
28 | 12181318 | Ser(214) is crucial for substrate binding to serine proteases. | 2002 Oct 25 | 1 |
29 | 11078728 | Residue Met(156) contributes to the labile enzyme conformation of coagulation factor VIIa. | 2001 Mar 2 | 1 |
30 | 11307817 | The amino acid sequence in fibrin responsible for high affinity thrombin binding. | 2001 Mar | 1 |
31 | 11496831 | Protease inhibitors, part 13: Specific, weakly basic thrombin inhibitors incorporating sulfonyl dicyandiamide moieties in their structure. | 2001 Jan | 1 |
32 | 10660541 | The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III. | 2000 Feb 11 | 2 |
33 | 10064272 | Insertion of the Asp-Ser/Phe sequence in the P' position of hirutonin provides molecules having both antithrombin and disintegrin activity. | 1999 Feb 15 | 1 |
34 | 10089309 | Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding. | 1999 Apr | 3 |
35 | 10465405 | Design, synthesis and biological evaluation of selective boron-containing thrombin inhibitors. | 1999 Jul | 1 |
36 | 9490687 | Prothrombin Greenville, Arg517-->Gln, identified in an individual heterozygous for dysprothrombinemia. | 1998 Mar 15 | 2 |
37 | 9020867 | Allosteric modulation of the activity of thrombin. | 1997 Jan 15 | 7 |
38 | 8805707 | Unique fold and active site in cytomegalovirus protease. | 1996 Sep 19 | 2 |
39 | 8855358 | Electrostatic interactions in hirudin-thrombin binding. | 1996 Aug 30 | 1 |
40 | 7673182 | The Na+ binding site of thrombin. | 1995 Sep 22 | 1 |
41 | 7893672 | Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. | 1995 Mar 21 | 1 |
42 | 8557169 | Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. | 1995 Oct | 1 |
43 | 21043620 | The Fluid-phase SC5b-9 Terminal Complement Complex Binds to the GPIIb/IIIa Complex of Thrombin-stimulated Human Blood Platelets Inhibiting Platelet Aggregation. | 1995 | 1 |
44 | 7756983 | The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. | 1994 Dec | 1 |
45 | 8055928 | Calcium inhibition of the activation of protein C by thrombin. Role of the P3 and P3' residues. | 1994 Jul 15 | 2 |
46 | 8360880 | Characterization of the interaction between human alpha-thrombin and methyl 3-(2-methyl-1-oxopropoxy)[1]benzothieno[3,2-b]furan-2-carboxylate (LY806303) using electrospray mass spectrometry and tandem mass spectrometry. | 1993 Aug 6 | 1 |
47 | 8381415 | Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity. | 1993 Feb 5 | 8 |
48 | 8384827 | Importance of the Arg-Gly-Asp triplet in human thrombin for maintenance of structure and function. | 1993 Mar | 2 |
49 | 1334492 | The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives. | 1992 Dec 25 | 3 |
50 | 1483477 | Biochemical characterization of single-chain chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin-specific antibody and single-chain urokinase. | 1992 Dec 15 | 1 |