Pub. Date : 2004 Mar 12
PMID : 14679197
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin. | Aspartic Acid | coagulation factor II, thrombin | Homo sapiens |
| 2 | Residue Asp-189 plays an important dual role in thrombin: it defines the primary specificity for Arg side chains and participates indirectly in the coordination of Na(+). | Aspartic Acid | coagulation factor II, thrombin | Homo sapiens |
| 3 | The observation that a single amino acid substitution can alter the monovalent cation specificity of thrombin from Na(+) (Asp-189) to Li(+) (Ser-189) or Rb(+) (Glu-189) is unprecedented in the realm of monovalent cation-activated enzymes. | Aspartic Acid | coagulation factor II, thrombin | Homo sapiens |