Title : Metabolism-directed optimisation of antithrombotics: the prodrug principle.

Pub. Date : 2006

PMID : 16454727






1 Functional Relationships(s)
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1 Thrombin, factor Xa, tissue factor/factor VIIa and platelet GPIIb/IIIa receptors display a preference for molecules containing highly basic arginine and/or acidic aspartate moieties, which are, however, associated with poor bioavailability after oral application. Aspartic Acid coagulation factor II, thrombin Homo sapiens