Title : Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB.

Pub. Date : 2012 Aug

PMID : 22694979






2 Functional Relationships(s)
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1 RESULTS: Treatment with simvastatin resulted in a decrease in 4-HNE and TNF-alpha concentration (median 4.18 mug/mg protein vs. 4.75, p = 0.012; median 10.33 pg/ml vs. 11.81, p = 0.026, respectively). Simvastatin tumor necrosis factor Homo sapiens
2 CONCLUSION: Simvastatin inhibits free radicals and TNF-alpha generation and improves antioxidant capacity of human AAA wall tissue, possibly through the suppression of NF-kappaB activity. Simvastatin tumor necrosis factor Homo sapiens