Title : Simvastatin inhibits pro-inflammatory mediators through induction of heme oxygenase-1 expression in lipopolysaccharide-stimulated RAW264.7 macrophages.

Pub. Date : 2011 Nov 30

PMID : 21925249






2 Functional Relationships(s)
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1 Moreover, simvastatin significantly inhibited LPS-induced inducible nitric oxide synthase (NOS) expression, and formation of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), nitrite and free radicals, but enhanced interleukin-10 (IL-10) production. Simvastatin tumor necrosis factor Homo sapiens
2 Moreover, simvastatin significantly inhibited LPS-induced inducible nitric oxide synthase (NOS) expression, and formation of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), nitrite and free radicals, but enhanced interleukin-10 (IL-10) production. Simvastatin tumor necrosis factor Homo sapiens