Lapatinib

epidermal growth factor receptor ; Homo sapiens







511 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
451 18774637 The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. 2008 Dec 18 2
452 18803986 Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. 2008 Aug 6
453 18823221 Lapatinib and ixabepilone for the treatment of metastatic breast cancer. 2008 Oct 4
454 18829547 Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. 2008 Oct 1 3
455 18849320 FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2. 2008 Oct 2
456 18952552 Unraveling the biologic and clinical complexities of HER2. 2008 Oct 1
457 18955454 Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. 2008 Dec 1 1
458 19046108 Jumping higher: is it still possible? The ALTTO trial challenge. 2008 Dec 1
459 19047149 Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor. 2008 Dec 1 2
460 19562083 EGFR Inhibition in the Treatment of Non-Small Cell Lung Cancer. 2008 Dec 9 1
461 19707428 Lapatinib in combination with capecitabine in the management of ErbB2-positive (HER2-positive) advanced breast cancer. 2008 Mar 2
462 21127749 Targeted treatment of advanced and metastaticbreast cancer with lapatinib. 2008 Sep 1 1
463 17060407 Prospective study of positron emission tomography for evaluation of the activity of lapatinib, a dual inhibitor of the ErbB1 and ErbB2 tyrosine kinases, in patients with advanced tumors. 2007 Jan 2
464 17203189 Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor. 2007 Feb 3
465 17208435 Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu). 2007 Feb 1
466 17250463 Lapatinib: a dual inhibitor of EGFR and HER2 tyrosine kinase activity. 2007 Feb 7
467 17283152 Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. 2007 Feb 1 2
468 17308062 Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. 2007 Feb 4
469 17320695 Combined treatment of bladder cancer cell lines with lapatinib and varying chemotherapy regimens--evidence of schedule-dependent synergy. 2007 Feb 2
470 17350323 Recent advances in the treatment of salivary gland cancers: emphasis on molecular targeted therapy. 2007 Sep 1
471 17402790 HER-2-positive breast cancer: hope beyond trastuzumab. 2007 1
472 17485900 Does lapatinib, a small-molecule tyrosine kinase inhibitor, constitute a breakthrough in the treatment of breast cancer? 2007 2
473 17489737 Circulating oncoproteins HER2/neu, EGFR and CAIX (MN) as novel cancer biomarkers. 2007 May 1
474 17513611 Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles. 2007 May 4
475 17547474 HER2-positive breast cancer: current and future treatment strategies. 2007 1
476 17555368 Her signaling in pancreatic cancer. 2007 Jun 1
477 17591827 Lapatinib in breast cancer. 2007 Jun 3
478 17593621 EGFR and HER-2 antagonists in breast cancer. 2007 May-Jun 1
479 17635524 Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines. 2007 Aug 12
480 17673607 Lapatinib-associated toxicity and practical management recommendations. 2007 Jul 1
481 17699871 Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network. 2007 Aug 15 1
482 17714070 Lapatinib: a tyrosine kinase inhibitor with a clinical role in breast cancer. 2007 Sep 1
483 17761983 Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands. 2007 Sep 1 2
484 17827454 Biology of interactions: antiepidermal growth factor receptor agents. 2007 Sep 10 1
485 18472989 A review of lapatinib ditosylate in the treatment of refractory or advanced breast cancer. 2007 Aug 2
486 19707333 Clinical activities of the epidermal growth factor receptor family inhibitors in breast cancer. 2007 Sep 1
487 16397255 Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. 2006 Jan 1 2
488 16452222 Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. 2006 Feb 1 4
489 16452223 Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers. 2006 Feb 1 2
490 16894399 Lapatinib: a novel EGFR/HER2 tyrosine kinase inhibitor for cancer. 2006 Jul 5
491 16934227 Receptor tyrosine kinase (RTK) inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian cancer cell lines when used in combination with cytotoxic agents. 2006 Oct 16 1
492 16940802 Identification of potentially useful combinations of epidermal growth factor receptor tyrosine kinase antagonists with conventional cytotoxic agents using median effect analysis. 2006 Sep 1
493 17092403 Delivery of a healthy baby after first-trimester maternal exposure to lapatinib. 2006 Oct 2
494 17110623 Lapatinib: current status and future directions in breast cancer. 2006 Nov-Dec 1
495 17192538 Lapatinib plus capecitabine for HER2-positive advanced breast cancer. 2006 Dec 28 1
496 15528979 Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects. 2005 Jan 2
497 15665275 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. 2005 Jan 1 4
498 15684311 Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. 2005 Apr 10 3
499 15755991 Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth. 2005 Mar 1 3
500 15833875 Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer. 2005 Apr 15 2