Title : A review of lapatinib ditosylate in the treatment of refractory or advanced breast cancer.

Pub. Date : 2007 Aug

PMID : 18472989






2 Functional Relationships(s)
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1 Lapatinib is a novel dual receptor tyrosine kinase inhibitor that is a selective and potent inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, both of which are growth promoting factors overexpressed in some breast cancers. Lapatinib epidermal growth factor receptor Homo sapiens
2 Cell-based assays have proven lapatinib to be a potent inhibitor of ErbB-1 and ErbB-2 activation and breast cancer cell proliferation. Lapatinib epidermal growth factor receptor Homo sapiens