Lapatinib

epidermal growth factor receptor ; Homo sapiens







511 Article(s)
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PMID
Title
Pub. Year
#Total Relationships
501 15857287 Small molecules with EGFR-TK inhibitor activity. 2005 May 1
502 15955900 Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. 2005 Aug 10 2
503 16091755 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. 2005 Sep 15 3
504 22500146 Lapatinib: the evidence for its therapeutic value in metastatic breast cancer. 2005 1
505 14737100 Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. 2004 Jan 22 3
506 14751502 Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. 2004 Feb 1 4
507 14967461 Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. 2004 Mar 1 1
508 15163842 Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. 2004 2
509 15374980 A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. 2004 Sep 15 11
510 12964069 Lapatinib ditosylate GlaxoSmithKline. 2003 Sep 1
511 12214266 Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. 2002 Sep 12 6