511 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
501 | 15857287 | Small molecules with EGFR-TK inhibitor activity. | 2005 May | 1 |
502 | 15955900 | Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. | 2005 Aug 10 | 2 |
503 | 16091755 | Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. | 2005 Sep 15 | 3 |
504 | 22500146 | Lapatinib: the evidence for its therapeutic value in metastatic breast cancer. | 2005 | 1 |
505 | 14737100 | Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. | 2004 Jan 22 | 3 |
506 | 14751502 | Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. | 2004 Feb 1 | 4 |
507 | 14967461 | Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. | 2004 Mar 1 | 1 |
508 | 15163842 | Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. | 2004 | 2 |
509 | 15374980 | A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. | 2004 Sep 15 | 11 |
510 | 12964069 | Lapatinib ditosylate GlaxoSmithKline. | 2003 Sep | 1 |
511 | 12214266 | Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. | 2002 Sep 12 | 6 |