Title : The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines.

Pub. Date : 2008 Dec 18

PMID : 18774637






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. Lapatinib epidermal growth factor receptor Homo sapiens
2 Lapatinib inhibited the phosphorylation of HER2, EGFR and downstream signaling proteins, resulting in G1 arrest in both cell lines with down-regulation of cMyc and induction of p27kip1. Lapatinib epidermal growth factor receptor Homo sapiens