AKT serine/threonine kinase 1 ; Homo sapiens

20 Article(s)
Pub. Year
#Total Relationships
1 35204223 Pre-Exposure to Stress-Inducing Agents Increase the Anticancer Efficacy of Focused Ultrasound against Aggressive Prostate Cancer Cells. 2022 Feb 9 1
2 35387819 Concurrent chemoradiation and brachytherapy alone or in combination with nelfinavir in locally advanced cervical cancer (NELCER): study protocol for a phase III trial. 2022 Apr 6 1
3 34136086 Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type. 2021 Jun 8 2
4 28137980 Nelfinavir inhibits proliferation and induces DNA damage in thyroid cancer cells. 2017 Mar 2
5 27280849 Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells. 2016 4
6 24418752 Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations. 2014 Mar 1
7 25327558 A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors. 2014 Sep 30 1
8 23647753 Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer. 2013 May 1
9 22271897 The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo. 2012 Jul 1
10 22338016 Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse large B-cell lymphoma. 2012 May 1 3
11 19480971 Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. 2009 Jul 1 1
12 18000394 Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy. 2008 Jan 1
13 18509182 Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer. 2008 Jun 1 1
14 17460771 The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response. 2007 Apr 3
15 17483362 Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir. 2007 May 1 3
16 17785575 Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. 2007 Sep 1 1
17 17132220 HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells. 2006 Nov 1
18 17133272 NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines. 2006 Dec 18 1
19 16166302 HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo. 2005 Sep 15 2
20 15168016 Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta. 2004 Jun 1